2BMI is obtained by dividing the subject’s weight by the square of the subject’s height and is expressed in metric units (BMI = kilograms / meters 2). The body mass index (BMI), a parameter comparing weight and height, describes an individual as pre-obese when their BMI is above 25 kg/ 2 and obese when greater than 30 kg/m. 2 The disease leads to an increased level of intrahepatic triglycerides progressinginto steatohepatitis. NAFLD is indicated by the presence of fat in liver biopsies and has been found to reduce the life expectancy of individuals. 1 It has also been associated with the pathogenesis of non-alcoholic fatty liver disease (NAFLD), observed in maximum obese individuals. Characterized by an immoderate accumulation of fat in the adipose tissue, obesity can deteriorate health by causing an increased risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) such as stroke, hypertension, and coronary heart disease as well as gall bladder disease, certain cancers (endometrial, breast, prostate, colon) and non-fatal conditions including gout, respiratory conditions, gastroesophageal reflux disease, osteoarthritis, and infertility. Obesity is one of the most challenging health problems faced worldwide. Anti-Obesity Properties of Calocybe Indica in Zebra fishes with Short-Term High-Fat Diet Induction. indica, the accumulation of triglycerides and lipids decreased.ĪLP- Alkaline Phosphatase ALT- Alanine Transaminase AST- Aspartate Transaminase BMI- Body Mass Index CVD- Cardiovascular Diseases DIO- Diet-Induced Obesity HFD- High Fat Diet HMG COA- Hydroxymethyl glutaryl coenzyme A NAFLD- Non-Alcoholic Fatty Liver Diseases NASH- Non-Alcoholic Steatohepatitis NFD- Normal Fat Diet T2DM- Type 2 Diabetes Mellitusĭownload this article as: Copy the following to cite this article: Whole-body Oil Red O staining of the zebrafishes showed that with increasing concentration of C. 9 IU/L normal control= 355.5☓4.4 IU/l), and ALP (2.3☑.1μmoles of phenol liberated/mg of protein/min normal control = 0.7☑.2 μmoles of phenol liberated/mg of protein/min).

indica was found to be optimum in decreasing the levels of the liver enzymes, AST (177.1±5.7 IU/L normal control =177.7±43.02 IU/l), ALT (365.5 ☒.

indica to a greater extent than by treatment with standard drug Atorvastatin. Excessive fat accumulation in the liver (steatohepatitis) reduced after treatment with C. indica was able to effectively bring down triglyceride levels (12.5± 0 mg/ml normal control 12.7 ± 0.7 mg/ml), cholesterol (210± 15.9 mg normal control = 70.4± 0) and HMG COA Reductase levels (0.9± 0.03 normal = 1.2 ± 0.01). Medicinal properties of Calocybe indica include antidiabetic, hypertensive, anticancer, anti-inflammatory, antibacterial, and hepatoprotective effects however, its anti-obesity activity is obscure.In this study, the anti-obesity effects of Calocybe indica were investigated using a diet-induced obese Zebrafish modeland compared with standard drug Atorvastatin.Results show that 200µg of C. Research on natural productspossessing therapeutic biological activitieshasdiscoveredtheir potential to minimize or even completely eliminate such side effects. Synthetic drugs used for treating obesity have been found to be associated with side effects such as anxiety,sleeplessness,hypertension, and drug addiction. Obese individuals are found to be highly susceptible to develop non-alcoholic fatty liver disease,cardiovascular diseases, and also type 2 diabetes mellitus. Obesity, a disease involved with complex health problems, is indicated by increased BMI, triglyceride and cholesterol levels. Anushree Nagaraj, Sarah Andrea Wilson and Lalitha Vaidyanathan*ĭepartment of Biomedical Sciences, Sri Ramachandra Institue of Higher Education and Research, Porur, Chennai- 600116, India.

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